A truck carrying gravel overturned at the intersection of the Murray Valley Hwy and Campbell Rd, Cobram on Monday afternoon.
Paramedics assessed the drivers of the three vehicles, with no fatalities reported.
Police blocked traffic bound east and west along the Murray Valley Hwy, and traffic travelling north and south along Campbell Rd.
Police said it was too early to determine the cause of the accident.
The Courier understands three vehicles, including the truck and two passenger cars, were involved in a collision at the infamous intersection, around 4.15pm on Monday.
Fire crews from Cobram and Yarroweyah were joined by the SES Cobram unit at the scene, and the highway was re-opened to traffic by Tuesday morning.