Meg Ryan pays heartfelt tribute to Rob Reiner

When Harry Met Sally
Rob Reiner directed Meg Ryan and Billy Crystal in the classic movie When Harry Met Sally. -AP

Meg Ryan has shared a poignant tribute to her When Harry Met Sally director Rob Reiner.

The 65-year-old actress praised the late filmmaker and his wife Michele Singer Reiner - whose son Nick Reiner has been charged with their murders after they were found dead at home on Sunday - for their way of always seeing the best in people.

She wrote on Instagram alongside a black-and-white photo of herself dancing with Rob while making When Harry Met Sally: "Oh how we will miss this man …

"Thank you, Rob and Michelle, for the way you believe in true love, in fairy tales, and in laughter. Thank you for your faith in the best in people, and for your profound love of our country."

Ryan went on to express her hope that "some good may come" from the couple's tragic deaths.

She added: "I have to believe that their story will not end with this impossible tragedy, that some good may come, some awareness raised … I don't know, but my guess is that they would want that to be hopeful and humane, to be something that brings us all to a greater understanding of one another and to some peace."