The prime minister will emphasise the importance of free and fair trade to US business leaders ahead of major talks with world powers.
Anthony Albanese landed in Seattle, in the US state of Washington, on Saturday as part of a whirlwind tour that could end in a meeting with US President Donald Trump about his controversial tariffs.
Washington state is home to several tech and engineering giants such as Boeing, Microsoft and Amazon, and Mr Albanese will attend the Technology and Innovation Business Reception on Saturday local time to address companies like BHP Ventures, Airwallex and Anthropic.
"Free and fair trade has transformed the economies of our region," the prime minister will say in his remarks.
"We should not lose sight of the profound opportunities that can be realised by closer and deeper co-operation - the businesses in this room are proof of that.
"In a time of global uncertainty, all of you represent cause for optimism."
The visit comes after he held security and climate talks in Fiji however, these pit stops play second fiddle to his trip's upcoming centrepiece.
Seven of the world's largest advanced economies will gather in Canada from Sunday for the multi-day G7 summit.
The event is often used to discuss solutions to major global issues like trade, security, economics and climate change, and in a year largely defined by trade tariffs, the topic is expected to take the spotlight.
Australia is not part of the G7 but Mr Albanese has been invited, fuelling speculation he will meet President Trump on the sidelines of the event.
The prime minister appears to be preparing for the possibility - his remarks reheat Labor's lines on US tariffs, emphasising Australia will engage "respectfully and constructively" in its national interest.
Australia currently faces 10 per cent tariffs on goods exported to the US and - like all US trading partners except the UK - has been hit with 50 per cent tariffs on aluminium and steel sent to America.
The Australian government is considering using critical minerals and US beef imports as bargaining chips in tariff talks.
However, Mr Albanese has not yet confirmed whether he will sit down with Mr Trump.
The prime minister has already had three discussions with the US president as his government, including Australia's ambassador to the US Kevin Rudd, have tried to negotiate a tariff exemption.
Mr Albanese will also visit the Amazon corporate headquarters in Seattle to highlight the company's multi-billion-dollar investment in Australian data centres.