Eric Dane died of respiratory failure.
The Grey's Anatomy star's death certificate, which has been seen by People, confirms that he died from respiratory failure, with amyotrophic lateral sclerosis (ALS) listed as an underlying cause.
Dane - who was 53 when he died on February 19 - revealed his ALS diagnosis nearly a year before his death.
Dane's family were the first to announce his death, revealing that he was surrounded by loved ones in the days before he died.
"With heavy hearts, we share that Eric Dane passed on Thursday afternoon following a courageous battle with ALS," it said in a statement.
"He spent his final days surrounded by dear friends, his devoted wife, and his two beautiful daughters, Billie and Georgia, who were the centre of his world.
"Throughout his journey with ALS, Eric became a passionate advocate for awareness and research, determined to make a difference for others facing the same fight," the statement said.
"He will be deeply missed, and lovingly remembered always. Eric adored his fans and is forever grateful for the outpouring of love and support he's received. The family has asked for privacy as they navigate this impossible time."
Dane revealed news of his diagnosis in April 2025.
"I have been diagnosed with ALS. I am grateful to have my loving family by my side as we navigate this next chapter," he told People.
"I feel fortunate that I am able to continue working and am looking forward to returning to set of Euphoria next week. I kindly ask that you give my family and I privacy during this time."
However, Dane subsequently decided to share his health journey with fans.
"It's imperative that I share my journey with as many people as I can because I don't feel like my life is about me anymore," he said.